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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b737a0b80e9b76e1036611e408d35dd6f09cf29ed78ef297ce0fb0cd76e3a395' 
  AND token = 'tM5Q3OJYJ6plLsMFXtxHEegR48s6hbb6dtVLdtwEGDI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00046

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}