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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ce8f058fc99c49fb90580f24a2d64426b14864b37c3e795ecec5daae5a4c31cb' 
  AND token = 'O4npI8ERu+cUXyskZZ81SpyDKd9A2rH7d1lqg1guJwQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}