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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c1a1537dc88354b27f842a4d7b3ab77d2927a0f777628b4e29da489da0c0ece4' 
  AND token = '43C2puM8ovnENgwPJ1+XnTju0/1NGS3eB3nuHKoxho4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}