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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2118c29c86e2cf5c12ef6a828c97bac055401244f25f63114c28fa14d748e775' 
  AND token = 'LzOskOVhhfsih9YGH/uMOpwXXSYM/2SJgUR21eVLKLQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}