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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '05f53e81822e9b6d92bee6947ae40295173e2bffc8e780f959b4a9caca30868d' 
  AND token = 'b/GHjPGh3Wp2Qp6QM4fFrhJSXsvaChYXK86R8WSEMLk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}