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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5e8b4ad78b93390de7f3d47f17a29ed4ecd1a346df8461d195bc915ecb5c0eaf' 
  AND token = 'lxe+rdcr+PY37/D5h/4Ku4yu2XokvWiYtTDd0AegzW0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}