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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2af6507e7015deb92ef24aef530ee8e9c491cd87311a1c5ebf8df8fe48e25f16' 
  AND token = 'N1Wz38EVvGgZGayWe5ai69aKYOBN4x8dWW2yzNHg0Ys=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}