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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25f201ad95124036d8f739470cca885838e36312b77c37efdf4cde438ef754c0' 
  AND token = '468uaU5paZY89RzP+Napym+J4M8+9GlywSXj7kmwfsg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}