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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f18af67b02225acd0d01a7c501cc0ded543ab1fb46385f2befe32d3827991016' 
  AND token = 'DMx/lAecvmCdxKJf3vHw3eeFNCz1nNpuLcjt36H3RhI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}