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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '75278349994839c2475657f4ca3c641e4fc0b2bbd6a3de1740d212fbce07bd05' 
  AND token = 'JU3E5Dy06U3Vbp0FVkRECj1dJiUxcoLSyIcyJ7vRbdo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}