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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8e2d1df960587b26b0bdddf1f850918dffed3263f56f3b3d0f15f56f6d2afb1a' 
  AND token = '1kXE5dlSMkaG4N/b0dV07gCIRJ+bA12efGvBTMj6XyE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}