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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ff852705189994651c520b6f8459613c99ed6f9c6dee939bf39a025531d06e01' 
  AND token = 'twq6gpF/j47MzWS4IauSCCsUHlgVqiCeb2bZnElmsCQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}