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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8b43a565baad99f49494d366e3d7afea95600e881369bd5b3e0dc5b5b1a7afc5' 
  AND token = 'JKFWaJ6M445lCOHCeVEUjiiZKSfKmEYT+Vw2r95/N7Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}