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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3225e76f1b1686d9b0a4b1643350025356f31e9c12b52e4056cf58985ea80bdf' 
  AND token = 'WH/tn2b/bFxd0duLYBjtkp6vz9BDYfkl1+4D8DOfcAs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}