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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '12ac449589a77e483c714fd2091527ce141a77b73db9de1841276a2ed1444710' 
  AND token = 's7n4/XN0IoGdEp3VEIZ4qkyIClZqVIFcSYjxYY5QqUI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}