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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5d8f5b81aa50a63c792cf08ce2f8b2f0389b03b76809eacbe1aaa5188c6b3c1d' 
  AND token = '+FbOyKShU55FvBM3S+9h725s3MD0oaNbzuZWFyMYgLc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}