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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a51f24f9f8aa48cc8603324a4a85c9721f6a66af7f77d65a8033d49bd1ca8fd4' 
  AND token = 'NIvXA/BsaDURXjKR2g2zv8DiUqqWDMjDG0rSDHRGEDM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}