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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ea3945a8aa57aee8e92ee42b3e94d1502043c35dc1bac49bf61a441729c88958' 
  AND token = '3+s8Na4wkSpTAfrffVya4h9XJ4aj+RGrsMpHiepz6UM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}