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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21111ad1281bc1203dce249d84b01a7f8e010994182540a9f49c891cdaefaa4e' 
  AND token = 'Chfkj4U8hxS1N+v/e4QkVUzACg+YyhhLC+nTW+2DzHk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}