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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c8726cc0685f038a18ab775530a6e1be361cd05ebe2421130deafca4bff50059' 
  AND token = 'HEMIrycASbk132w144A6AHUlYPac0IEBnd68MCe6eTs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}