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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a8d77bc03c4d9f81e6628d4484bac61158019b42a8ed52e5523941818498ef41' 
  AND token = '55hvHigQRyZxhkd1+uYUznZnl89TD4PQoQkPaQHqyVY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}