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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b78f3a969ac831b407f821098fec4178f6a48d52e8540d1dcb878fdbb44db917' 
  AND token = 'tz4bzW/xGFJ6aito/WFvKSxACs61mHp2RECOPfUb2Zo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}