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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48229bc1f7991e453b51035f80e4c08f8514bca4b18bf35a3c6a66aa7e70c581' 
  AND token = 'jD9mpUKymQ8Qg1X8+l80Rf34tYV59kJdOJF68eBU6Cc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}