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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a00b4fa6ecd0f1d2d0b8b335b353475a53f81d8e88e475b99701e714a8b5e458' 
  AND token = 'DWpLUUd/0cofQEFtSqi3N+RK8cnvW0PXpmXdlpZOkYY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}