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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4fd14acb952c2dd3a7d04811b9e2e649275c9a6e4402649ca81d651dbe2fd201' 
  AND token = 'YmEaFtH3McH3IfYrPB+R0nmq6nsThrYSy1OoAxUM0HM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}