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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0c0649a6abf1cf117ac70d4e9f7ceef9220040a4b871f5022199d0acdc74943b' 
  AND token = '5M5lluvBZMm+3rDUm3i0ls1qVZDVcLOQrqLo004PBcQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}