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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ecc8e479a6c1fa63c93356f2370d93297a7e387559a6f7b55a87e7e6febef273' 
  AND token = 'LtK9Vj1BdQUagwp/zXbQocZpwPn7f8yOnbnsZgi7UsY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}