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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80a649bbc3fe608a05ede243c925c1fc25ea08d56d4250e401efd2d6a046ace8' 
  AND token = 'VK+Ry7RE3DZwYImoePoYCthE+2UTPQnWbv6ju54E6JI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}