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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'efbb0c389dcce088632f71b215a3a846e021216b0ece7b50e2ba07b4fe02b8ab' 
  AND token = 'ZTx+sALq7JmUpLrRZ9KNzo5W1SeLQTY4WRurw4m8weM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}