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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'da39e46bf1c38425f613bc7183e3eb84f780b74c0b59d4f3948399949a972dac' 
  AND token = 'x/GdtqR2+qPB1IlyatJ6UEwr10y5P3uEokX8gVpgJOA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}