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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21b8e896b87bbaceced70bd516bdac6e28b6c583f424f214ecaa8b7fe989e458' 
  AND token = 'Em2+mIcJ23FVG+9nV+Nnz7cHJDHmP/7recjpVa7TrDw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}