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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7f51b6fc6c8cac99024c609debc81f825175861a2211d88bcdc5f3a25d538147' 
  AND token = 'V1kcqWKj7MehhzBDjWa5QC+nOVAeVWn0PRQM48e+tSg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}