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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b9726378385bc0eb23dfa3f2c7b6fca4fffd0a201a33900ee65b25c7d02b1988' 
  AND token = 'dZcMZuEJ2s1tpbIidDLF7lxFh5On6AdFbgrmsTVOqmM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}