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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '157386107a355f9be01755ee3f1f7313908ca6099f80a4ebe9df4e8cda9ba175' 
  AND token = 'SUAoGDIvgShgl7C1EQ7puuTUXxefqtK9lFrJRwwTi/s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}