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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '737e430ea82d639eb4d77b30bc67f34305672a8259cc90150bd3ce520ac9afc9' 
  AND token = 'b5TcPPHmS/iDIlVSEo+4tl8TsPYPuu9MwPpVh+YBMaA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}