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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21bdae384988a7feec0c2fa80ef63aad48a71caf6d4612df378a4eae241c0fe2' 
  AND token = '8VXvB/yOefVRVMl6MJ6bZ6veOMW79eoYZzadimJnOlA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}