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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '424823c15bae76740a50c78209e4ffe4817346661cd33e4c386530ab1bec4ad3' 
  AND token = 'E3Q1HzZ5W6RW9j6kR0+pqjeTWPGbfEnhJKSAAzI9E4Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}