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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4e0e9e7883f74960333e61529b30e37528c13e29cee2127a930620a2baebd7f8' 
  AND token = 'AqQ+TeO3kiuRG3W0P4M9G3HJH7I3XxBCptCGah3mtJc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}