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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '05e29678d6aee0e623eefec469e7c5debffee4e6b5bc050a31ffdb7c46a7cb50' 
  AND token = 'R2LH4sbWmCucR9RBTx6yxRsqXEq2b37b5Kmp42RxNHw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}