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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '025141cbd2e50a818a9c97061f455d5a7f5dcc70f5832b536b65c1aee9e60331' 
  AND token = 'CJqFoadOSjX1wEHWGviGmAeWDdUEDG+BS4UmjeBrfIg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}