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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0c54d38d5aa2fea2b891a67edd1aaec36275a29b582d3b8033772b1aa322a5f1' 
  AND token = 'f6uIjGIsxm2p0o/1mq+SF4pde/z1niFHrpk21KPjHUk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}