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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8dd0c27ea1069979ad21012bdf457a476207e5f8597c906b6b1de99283d72b19' 
  AND token = 'o6E30m0iZGL/SaqppbN2PG7y60l/RB8dGpAQTXsj4iA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}