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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1000e387b25d8f74fdb8365deda84de1bbb67a0b976133e89ef04ca0c9bf5511' 
  AND token = 'n4e7Np1D0jF99NO5a05VfN+A9HRZWgLPN8Y1ZvRRXxY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}