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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f18000fd797ef864f396dbe407f63d1449345351bb51d7d421802da1f0172846' 
  AND token = 'UAponVcVwi1NoaGPOYnjc7CKVjrPMM6RqEFUdUrlMkU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}