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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1f46486146290ecbf44b2abaf711f942aa2296a290f5b188c747d83d1c41fca8' 
  AND token = 'kx+VLYCyFQgH4/YmxBjc4SdtYdv4hlXCXa0I/Q7cGh0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}