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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '59eff917d52a590d30859d42ac0b39401b4451278e04dfcbf25b39c7cf07f624' 
  AND token = 'vYs2VIrCeSLa37mbPpfZDCMjQp10OWIVmTnd0Q8ZF8M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}