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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8a2f3fd264b5e884b778bd4b834eb6d6eb9ecfece833fff3f27751d386680896' 
  AND token = 'MjC+f7NaW1khPayq2QhIQa0Wzs7t4hfNOJKK3Ix15L0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}