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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6d5abc60d80e6bd89c1b7c7f95f5a8b595403384f50cdd4a964dcb8c310edd49' 
  AND token = 'Ha4GMmdxrwEt6e31Q0RfnXaZwdUFNFl70fdS38F2zuo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}