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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6e121b2273d782d9270a86d5854b7875ede6e7148f92245fc5b936d242735e7d' 
  AND token = 'mwcrXZ6RHalq58EIBn5ZaM6SEFaZcNgJpMgT1aaR7PA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}