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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1757a9c340a6ff03f8a2843bd69a868eeb64f1d962018309379f66af7bf9375f' 
  AND token = 'ERXbCWfvFTGRB2sineOPA8T5BM03XqkA+u6W1kRBnys=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}